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Our research represented in these pages is organized in five categories.
I. [ Macroepidemiology: National Mortality Data for US and JAPAN ]
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II. [ Macroepidemiology: US Community Data ]
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III. [ Mathematical Models of Clonal Disease ]Developing biologically based mathematical | ||
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IV. [ Inherited and Somatic Risk for Common Diseases ]
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V. [ Somatic Mutation in Human Tissues ]Developing and testing the fetal-juvenile mutator stem cell hypothesis with regard to the origins of mutations in adult tissues, atherosclerotic plaque, preneoplasia and neoplasia and devising instrumentation to determine the microanatomical distribution of selected (MAMA) and unselected (CyDCE) point mutations in tissues and derived clonal lesions. | ||
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models of clonal diseases for analyses of historical age-specific mortality data for cohorts defined
by gender and general ethnicity. 
Developing the theory of multi-allelic, multi-genic risk for common diseases and devising instrumentation to perform pangenomic exonic scans
using appropriately large cohorts to identify the genes carrying inherited risk for each common disease. This includes identification of genes
in which somatic mutations are required for carcinogenesis or artherogenesis. 